Protein Modification Reagents
Medchemexpress LLC Acid-PEG2-SS-PEG2-acid | 1807539-10-1 | 95.0% | 386.48 g/mol | C14H26O8S2 | 5 MG
Acid-PEG2-SS-PEG2-acid is a cleavable 4-unit polyethylene glycol (PEG) linker containing a central disulfide bond and terminal carboxylic acids, designed for use in antibody-drug conjugate (ADC) synthesis and bioconjugation. Supplied as a white to off-white solid for research use only.
- Cleavable disulfide bond enables intracellular release under reducing conditions.
- Terminal carboxyl groups allow amide coupling and conjugation chemistry.
- Four-unit PEG spacer improves solubility and reduces steric hindrance.
- High purity suitable for research applications.
- Solid, white to off-white appearance with recommended cold storage.
eMolecules Meo-dpeg(4)-nh2 | 85030-56-4 | 1G | Purity: 96%
Combi-Blocks | Meo-dpeg(4)-nh2 | 1G | 85030-56-4 | MFCD11041099
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![Medchemexpress LLC 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[poly(ethylene glycol)-1000]-fluorescein | 1000788-53-3 | 95.0% | 25 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000281136.png-250.jpg)
Medchemexpress LLC 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[poly(ethylene glycol)-1000]-fluorescein | 1000788-53-3 | 95.0% | 25 MG
DSPE-PEG-FITC (MW 1000) is a fluorescein-labeled PEGylated phospholipid designed for incorporation into liposomes, micelles, and nanoparticle formulations for fluorescent tracking. The construct combines a distearoyl phosphoethanolamine lipid anchor with a poly(ethylene glycol) spacer terminating in fluorescein; typical purity is 95% (CAS 1000788-53-3).
- Enables fluorescent labeling of liposomes and nanoparticles for imaging and tracking.
- Incorporates stably into lipid bilayers via a distearoyl phosphoethanolamine anchor.
- Poly(ethylene glycol) spacer reduces nonspecific interactions and improves circulation.
- Fluorescein provides bright green fluorescence compatible with microscopy and flow cytometry.
- Supplied in research-scale quantities suitable for formulation and analytical work.
Medchemexpress LLC 4-Arm PEG-SCM MW 10 500mg
4-Arm PEG-SCM (MW 10000) is a multi-arm PEG derivative that can be used for peptide modification and drug delivery[1]
Cayman Chemical PomalIdomIde 1mg
An inhibitor of cereblon (IC50 = ~3 µM for the human recombinant CRBN-DDB1 complex); inhibits autoubiquitination of CRBN in HEK293T cells expressing CRBN; inhibits proliferation of U266 myeloma cells at 0.1-10 µM; reduces tumor growth in a H929 R10-1 lenalidomide-resistant mouse xenograft model at 3 mg/kg per day when used in combination with dexamethasone
Medchemexpress LLC Sulfo DBCO-amine | 2028284-70-8 | MFCD30458046 | 99.0% | 427.47 g/mol | C21H21N3O5S | 5 MG
Sulfo DBCO-amine is a water-soluble click-chemistry reagent containing a dibenzocyclooctyne (DBCO) moiety that enables strain-promoted alkyne-azide cycloaddition (SPAAC) for efficient, copper-free bioconjugation. It is commonly used as a linker or building block in PROTAC synthesis and other bioconjugation workflows, and is supplied in small quantities for research use.
- Enables copper-free SPAAC bioconjugation.
- Water-soluble sulfonate improves aqueous compatibility.
- Contains a reactive amine for stable amide coupling.
- High purity suitable for research-grade applications.
- Available in small quantities for exploratory synthesis.
eMolecules N-Boc-N-bis(PEG3-acid) | Broadpharm | 2055023-35-1 | MFCD29912757 | 525.592 | C23H43NO12 | 97.000 | CC(C)(C)OC(=O)N(CCOCCOCCOCCC(O)=O)CCOCCOCCOCCC(O)=O | 500mg | 309208999
N-Boc-N-bis(PEG3-acid) | Broadpharm | 2055023-35-1 | MFCD29912757 | 525.592 | C23H43NO12 | 97.000 | CC(C)(C)OC(=O)N(CCOCCOCCOCCC(O)=O)CCOCCOCCOCCC(O)=O | 500mg | 309208999
eMolecules Broadpharm / Aminooxy-PEG4-CH2CO2tBu / 100mg / 336613504 / BP-23421 / 98.000 / 2062663-62-9 / MFCD30536168 / 323.386 / C14H29NO7
Broadpharm / Aminooxy-PEG4-CH2CO2tBu / 100mg / 336613504 / BP-23421 / 98.000 / 2062663-62-9 / MFCD30536168 / 323.386 / C14H29NO7
Medchemexpress LLC 3,6,9,12-Tetraoxatetradecanoic acid, 14-hydroxy- | 70678-95-4 | ≥97.0% | C10H20O7 | 250 MG
Hydroxy-PEG4-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
Medchemexpress LLC DSPE-PEG-CHO (aldehyde-terminated DSPE-PEG) | 2000 (average) | 10 MG
DSPE-PEG-CHO (MW 2000) is a heterobifunctional PEGylated phospholipid composed of a DSPE lipid anchor linked to a polyethylene glycol chain terminated with an aldehyde group. Supplied as a powder, it is designed for introducing reactive aldehyde functionality onto liposomes, lipid nanoparticles, or other lipid-based carriers to enable conjugation of biomolecules for targeted delivery and surface modification.
- Aldehyde-terminated PEG enables covalent conjugation to primary amines.
- PEG MW 2000 provides hydrophilicity and steric stabilization of particles.
- DSPE lipid anchor facilitates efficient incorporation into lipid bilayers and nanoparticles.
- DMSO solubility approximately 12.5 mg/mL with ultrasonic warming to 60°C.
- Powder storage at -20°C (up to 3 years); in solvent storage at -80°C for 6 months or -20°C for 1 month.
